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Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis.
- Source :
-
Current drug targets [Curr Drug Targets] 2023; Vol. 24 (3), pp. 287-296. - Publication Year :
- 2023
-
Abstract
- Introduction: The association between triamcinolone hexacetonide (TH) and gold nanoparticles (GNPs) represents a promising treatment due to the potential anti-inflammatory and antioxidant effects of these compounds. In this study, we evaluated the effects of intra-articular treatment of TH associated with GNPs in a mechanical model of osteoarthritis (OA).<br />Methods: Fifty Wistar rats were divided into five groups: Sham; OA; OA+TH; OA+GNPs; OA+TH-GNPs. Both applications were performed 30 and 60 days after the model was induced. After 30 days of the last application, the animals were euthanized.<br />Results: Only the combined treatment with TH and GNPs promoted a reduction in proinflammatory cytokines and an increase in anti-inflammatory cytokines. The OA+TH-GNPs group obtained a significant reduction in the production of oxidants and oxidative damage markers while an increase in antioxidants. Histologically, all treated groups showed results of a significant increase in cartilage thickness and chondrocyte count, the OA+TH-GNPs group had similar behavior to the group without osteoarthritis, with significantly smaller amounts of chondrocytes than the OA group.<br />Conclusion: The intra-articular use of TH associated with GNPs may be able to prevent the progression of the pathology and minimize joint degradation.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Rats
Animals
Gold
Rats, Wistar
Models, Animal
Antioxidants pharmacology
Antioxidants therapeutic use
Antioxidants metabolism
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents therapeutic use
Anti-Inflammatory Agents metabolism
Cytokines metabolism
Chondrocytes metabolism
Chondrocytes pathology
Cartilage, Articular metabolism
Metal Nanoparticles
Osteoarthritis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5592
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current drug targets
- Publication Type :
- Academic Journal
- Accession number :
- 36515017
- Full Text :
- https://doi.org/10.2174/1389450124666221212090319