Correlation of serum miR-127 level with severity and prognosis of sepsis.

Objective: To investigate the relationship of serum miR-127 level with the severity of sepsis patients and its predictive efficacy for prognosis.
Methods: A total of 205 healthy individuals who underwent physical examination in Jingzhou Hospital Affiliated to Yangtze University and 205 patients with sepsis who were hospitalized in ICU from January 2021 to March 2022 were recruited in this study, and their serum miR-127 level were measured. The patients were divided into a high-miR-127 group (110 cases) and a low-miR-127 group (95 cases) based on the optimal cut-off value of miR-127 to assess the prognosis. The clinical data and 28-day survival of the two groups were analyzed. The patients were further divided into a death group (57 cases) and a survival group (148 cases) based on their 28-day survival. Factors associated with poor prognosis of sepsis were analyzed by Cox regression.
Results: There were statistically significant differences in heart rate, body temperature, white blood cells (WBC), hemoglobin (Hb), procalcitonin (PCT), C-reactive protein (CRP), alanine aminotransferase (ALT), total bilirubin (TBIL), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), cardiac troponin I (cTnI), blood urea nitrogen (BUN), Prothrombin time (PT), serum creatinine (Scr), fibrinogen (FIB) and miR-127 between sepsis patients and healthy controls ( P < 0.05). Compared to those in the low-miR-127 group, PCT, BUN, and SOFA scores in the high-miR-127 group were significantly higher ( P < 0.05). The 28-day cumulative survival was lower in the high-miR-127 group (58.20%) than that in the low-miR-127 group (88.40%) (Log Rank χ ² =25.598, P < 0.05). Those with high miR-127 still had a higher risk of poor prognosis compared to those with low miR-127 after correcting for SOFA score, APACHE II score and PCT (HR=3.292, 95% CI: 1.663-6.517, P < 0.05). The areas under the ROC curve (AUC) of serum miR-127, SOFA score, and APACHE II score for predicting prognosis of sepsis patients were 0.748 (0.674-0.823), 0.810 (0.742-0.878) and 0.864 (0.811-0.916), respectively.
Conclusion: Serum miR-127 is highly expressed in sepsis and related to the severity of sepsis. Those with high miR-127 level have a higher risk of poor prognosis.
Competing Interests: None.
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