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Activity Sensing of Coagulation and Fibrinolytic Proteases.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Mar 28; Vol. 29 (18), pp. e202203473. Date of Electronic Publication: 2023 Feb 07. - Publication Year :
- 2023
-
Abstract
- The blood coagulation cascade is a complex physiological process involving the action of multiple coupled enzymes, cofactors, and substrates, ultimately leading to clot formation. Serine proteases have a crucial role, and aberrations in their activity can lead to life-threatening bleeding disorders and thrombosis. This review summarizes the essential proteases involved in blood coagulation and fibrinolysis, the endogenous peptide sequences they recognize and hydrolyze, and synthetic peptide probes based on these sequences to measure their activity. The information in this review can contribute to developing novel anticoagulant therapies and specific substrates for point-of-care diagnosis of coagulation pathologies.<br /> (© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 29
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 36484562
- Full Text :
- https://doi.org/10.1002/chem.202203473