Back to Search Start Over

[Mouse models of hematological diseases using genome editing technology].

Authors :
Nagamachi A
Inaba T
Source :
[Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2022; Vol. 63 (11), pp. 1551-1557.
Publication Year :
2022

Abstract

The impact of gene-editing technology has rapidly expanded into developmental engineering. Using this technology, gene targeting in mice can be performed within 2-3 months, which is a much shorter timespan than that required while using embryonic stem cell-based conventional methods, which require nearly two years. In addition, genome-editing technology omits several skillful laborious steps. This review describes the prominent merits of gene targeting using this recently established and still ongoing technology in the field of hematology. In addition, the experience of the authors is reviewed to identify and characterize genes involved in the loss of the long arm of chromosome 7 in myeloid malignancies and highlight the significance of establishing the mouse model of human diseases.

Details

Language :
Japanese
ISSN :
0485-1439
Volume :
63
Issue :
11
Database :
MEDLINE
Journal :
[Rinsho ketsueki] The Japanese journal of clinical hematology
Publication Type :
Academic Journal
Accession number :
36476797
Full Text :
https://doi.org/10.11406/rinketsu.63.1551