Clinical trials evaluating desensitising agents. Some design and analysis issues.

Introduction: The purpose of this short communication is to draw attention to an efficient design for trials to evaluate desensitising agents, and an appropriate statistical analysis.
Methods: Two recent sensitivity trials conducted by the Bristol Dental School Clinical Trials Group are reviewed.
Results: The methodology used was effective to establish efficacy of the products evaluated.
Conclusions: This methodology is recommended for wider use.
Clinical Significance: Effective clinical trial methodology enables establishment of efficacy of desensitising products leading to patient benefit.
Competing Interests: Conflict of interest statement The authors declare that they have no competing interests with regard to this paper. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)