A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle.

Authors :: Puri PL
Source :: Cell stem cell [Cell Stem Cell] 2022 Dec 01; Vol. 29 (12), pp. 1613-1615.
Publication Year :: 2022
Abstract: In this issue of Cell Stem Cell, Porpiglia et al. <superscript>1</superscript> report on alterations in CD47 and THBS1 expression and function in aged muscle stem cells that disrupt their regeneration capacity. Targeting THBS1-CD47 cross-signaling is sufficient to reverse sarcopenia and restore muscle mass and function in aged mice.<br />Competing Interests: Declaration of interests The author declares no competing interests.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)