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Highly recurrent BRAF p.V595E mutation in canine papillary oral squamous cell carcinoma.
- Source :
-
Veterinary and comparative oncology [Vet Comp Oncol] 2023 Mar; Vol. 21 (1), pp. 138-144. Date of Electronic Publication: 2022 Dec 07. - Publication Year :
- 2023
-
Abstract
- Oral squamous cell carcinoma (OSCC) is the most common oral epithelial malignancy in dogs. It exhibits locally aggressive biological behaviour with the potential to metastasize, and a reported 1-year survival rate of 0% when left untreated. Expression studies suggest that aberrant MAPK signalling plays a key role in canine OSCC tumorigenesis, which is consistent with BRAF and HRAS MAPK-activating mutations reported in some tumours. Several morphological subtypes of canine OSCC have been described, with papillary, conventional, and basaloid as the most common patterns. We hypothesized that mutational differences may underlie these phenotypic variations. In this study, targeted Sanger sequencing and restriction fragment length polymorphism assays demonstrate that up to 85.7% of canine papillary OSCC (n = 14) harbour a BRAF p.V595E mutation. Assessment of neoplastic epithelial cell proliferation using Ki67 immunolabelling (n = 10) confirmed a relatively high proliferation activity, consistent with their known aggressive clinical behaviour. These findings underscore a consistent genetic feature of canine papillary OSCC and provide a basis for the development of novel diagnostic and targeted therapeutic approaches that can improve the quality of veterinary care.<br /> (© 2022 John Wiley & Sons Ltd.)
- Subjects :
- Animals
Dogs
Proto-Oncogene Proteins B-raf genetics
Squamous Cell Carcinoma of Head and Neck veterinary
Mutation
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell veterinary
Carcinoma, Squamous Cell metabolism
Mouth Neoplasms genetics
Mouth Neoplasms veterinary
Mouth Neoplasms pathology
Dog Diseases pathology
Head and Neck Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5829
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Veterinary and comparative oncology
- Publication Type :
- Academic Journal
- Accession number :
- 36451536
- Full Text :
- https://doi.org/10.1111/vco.12869