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The inhibitory effects of various ions released from S-PRG fillers on dentin protease activity.
- Source :
-
Dental materials journal [Dent Mater J] 2023 Jan 31; Vol. 42 (1), pp. 99-104. Date of Electronic Publication: 2022 Dec 01. - Publication Year :
- 2023
-
Abstract
- This study investigates the effect of ions released from S-PRG fillers on host-derived enzymatic degradation of dentin collagen matrices. Dentin beams (n=80) were demineralized and distributed to eight groups following baseline dry mass and total MMP activity assessments. Each group treated with boron, fluoride, sodium, silicone, strontium, aluminium, or S-PRG eluate solutions for 5 min. Untreated beams served as control. After pre-treatment, MMP activity was reassessed, beams were incubated in complete medium for 1 week, dry mass was reassessed. Incubation media were analyzed for MMP and cathepsin-K-mediated degradation fragments. Data were analyzed with ANOVA and Tukey's test. All pretreatment groups showed significant reduction in total MMP activity (p<0.05) that was sustainable after incubation in all groups except for boron and silicone groups (p<0.05). Cathepsin-K activity did not differ between control or treatment groups. The results indicated that ions released from S-PRG fillers have the potential to partly inhibit MMP-mediated endogenous enzymatic activity.
Details
- Language :
- English
- ISSN :
- 1881-1361
- Volume :
- 42
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Dental materials journal
- Publication Type :
- Academic Journal
- Accession number :
- 36450455
- Full Text :
- https://doi.org/10.4012/dmj.2022-141