In Reply.

Competing Interests: Financial Disclosure Arthur Caplan serves as the unpaid chair of the Compassionate Use Advisory Committees (CompAC), independent panels of internationally recognized medical experts, bioethicists, and patient representatives formed by NYU School of Medicine in collaboration with Janssen. CompAC advises Janssen about requests for compassionate use of its investigational medicines. NYU receives administrative funding from Janssen to facilitate the CompAC committees. He discusses emerging issues in research ethics with WIRB/WCG leadership, and also gives lectures on research ethics topics to WIRB/WCG staff and fellows. He has consulted for pay with eGenesis Bioethics Advisory Board, Genae/Cardialen-DSMB, Biomarin, Cabaletta Bio, Accenture, MaxCyte, NeuBase Therapeutics, Inc. Hevolution foundation. He was recently an Expert Witness for the Vermont Board of Medical Practice and State of Vermont. The other authors did not report any potential conflicts of interest.