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Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome.
- Source :
-
Journal of autism and developmental disorders [J Autism Dev Disord] 2024 Feb; Vol. 54 (2), pp. 725-737. Date of Electronic Publication: 2022 Nov 28. - Publication Year :
- 2024
-
Abstract
- Fragile X syndrome (FXS) is characterized by variable neurobehavioral abnormalities, which leads to difficulties in developing and evaluating treatments and in determining accurate prognosis. We employed a pediatric cross-sectional sample (1,072 males, 338 females) from FORWARD, a clinic-based natural history study, to identify behavioral subtypes by latent class analysis. Input included co-occurring behavioral conditions, sleep and sensory problems, autistic behavior scales (SCQ, SRS-2), and the Aberrant Behavior Checklist revised for FXS (ABC <subscript>FX</subscript> ). A 5-class solution yielded the most clinically meaningful, pharmacotherapy independent behavioral groups with distinctive SCQ, SRS-2, and ABC <subscript>FX</subscript> profiles, and adequate non-overlap (≥ 71%): "Mild" (31%), "Moderate without Social Impairment" (32%), "Moderate with Social Impairment" (7%), "Moderate with Disruptive Behavior" (20%), and "Severe" (9%). Our findings support FXS subtyping, for improving clinical management and therapeutic development.<br /> (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Details
- Language :
- English
- ISSN :
- 1573-3432
- Volume :
- 54
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of autism and developmental disorders
- Publication Type :
- Academic Journal
- Accession number :
- 36441429
- Full Text :
- https://doi.org/10.1007/s10803-022-05821-7