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Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation.
- Source :
-
Molecular and cellular neurosciences [Mol Cell Neurosci] 2023 Mar; Vol. 124, pp. 103794. Date of Electronic Publication: 2022 Nov 23. - Publication Year :
- 2023
-
Abstract
- Reelin, a large secreted glycoprotein, plays an important role in neuronal migration during brain development. The C-terminal region (CTR) of Reelin is involved in the efficient activation of downstream signaling and its loss leads to abnormal hippocampal layer formation. However, the molecular mechanism by which Reelin CTR regulates hippocampal development remains unknown. Here, we showed that the migration of late-born, but not early-born, neurons is impaired in the knock-in mice in which Reelin CTR is deleted (ΔC-KI mice). The phosphorylation of cofilin, an actin-depolymerizing protein, was remarkably decreased in the hippocampus of the ΔC-KI mice. Exogenous expression of pseudo-phosphorylated cofilin rescued the ectopic positioning of neurons in the hippocampus of ΔC-KI mice. These results suggest that Reelin CTR is required for the migration of late-born neurons in the hippocampus and that this event involves appropriate phosphorylation of cofilin.<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Mice
Cell Adhesion Molecules, Neuronal genetics
Cell Adhesion Molecules, Neuronal metabolism
Hippocampus metabolism
Nerve Tissue Proteins genetics
Nerve Tissue Proteins metabolism
Neurons metabolism
Phosphorylation
Serine Endopeptidases genetics
Serine Endopeptidases metabolism
Actin Depolymerizing Factors metabolism
Extracellular Matrix Proteins genetics
Extracellular Matrix Proteins metabolism
Reelin Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9327
- Volume :
- 124
- Database :
- MEDLINE
- Journal :
- Molecular and cellular neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 36435394
- Full Text :
- https://doi.org/10.1016/j.mcn.2022.103794