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Potent antibacterial activity of MXene-functionalized graphene nanocomposites.

Authors :: Salmi MS
Ahmed U
Aslfattahi N
Rahman S
Hardy JG
Anwar A
Source :: RSC advances [RSC Adv] 2022 Nov 18; Vol. 12 (51), pp. 33142-33155. Date of Electronic Publication: 2022 Nov 18 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Two dimensional (2D) nanomaterials display properties with significant biological utility ( e.g. , antimicrobial activity). In this study, MXene-functionalized graphene (FG) nanocomposites with Ti <subscript>3</subscript> C <subscript>2</subscript> T <subscript> x </subscript> in varying ratios (FG : Ti <subscript>3</subscript> C <subscript>2</subscript> T <subscript> x </subscript> , 25 : 75%, 50 : 50%, and 75 : 25%) were prepared and characterized via scanning electron microscopy, scanning electron microscopy-energy dispersive X-ray (SEM-EDX), high-resolution transmission electron microscopy (HRTEM), and zeta potential analysis. Their cytotoxicity was assessed using immortalized human keratinocytes (HaCaT) cells at three different timepoints, and antibacterial activity was assessed using Gram-positive Methicillin resistant Staphylococcus aureus , MRSA, and Gram-negative neuro-pathogenic Escherichia coli K1 ( E. coli K1) in vitro . The nanomaterials and composites displayed potent antibacterial effects against both types of bacteria and low cytotoxicity against HaCaT cells at 200 μg mL <superscript>-1</superscript> , which is promising for their utilization for biomedical applications.<br />Competing Interests: There are no conflicts to declare.<br /> (This journal is © The Royal Society of Chemistry.)