Prospective bacterial and fungal sources of hyaluronic acid: A review.

Authors :: Shikina EV
Kovalevsky RA
Shirkovskaya AI
Toukach PV
Source :: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2022 Nov 10; Vol. 20, pp. 6214-6236. Date of Electronic Publication: 2022 Nov 10 (Print Publication: 2022).
Publication Year :: 2022
Abstract: The unique biological and rheological properties make hyaluronic acid a sought-after material for medicine and cosmetology. Due to very high purity requirements for hyaluronic acid in medical applications, the profitability of streptococcal fermentation is reduced. Production of hyaluronic acid by recombinant systems is considered a promising alternative. Variations in combinations of expressed genes and fermentation conditions alter the yield and molecular weight of produced hyaluronic acid. This review is devoted to the current state of hyaluronic acid production by recombinant bacterial and fungal organisms.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2022 The Authors.)