Trifluoromethylation of Carbonyl and Unactivated Olefin Derivatives by C(sp 3 )-C Bond Cleavage.

Authors :: Cong F
Mega RS
Chen J
Day CS
Martin R
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Apr 03; Vol. 62 (15), pp. e202214633. Date of Electronic Publication: 2022 Dec 12.
Publication Year :: 2023
Abstract: Herein, we report a Cu-mediated trifluoromethylation of carbonyl-type compounds and unactivated olefins enabled by visible-light irradiation via σ C(sp <superscript>3</superscript> )-C bond-functionalization. The reaction is distinguished by its modularity, mild conditions and wide scope-even in the context of late-stage functionalization-thus offering a complementary approach en route to valuable C(sp <superscript>3</superscript> )-CF <subscript>3</subscript> architectures from easily accessible precursors.<br /> (© 2022 Wiley-VCH GmbH.)

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