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Ag(I)-catalyzed cyclization of o -alkynylacetophenones facilitated through acetal formation: synthesis of C3-naphthyl indole derivatives.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Dec 14; Vol. 20 (48), pp. 9698-9702. Date of Electronic Publication: 2022 Dec 14. - Publication Year :
- 2022
-
Abstract
- A mild method for an efficient synthesis of C3-naphthyl indoles from o -alkynylacetophenones has been developed. This Ag-catalyzed transformation is assisted by the acetal formed under the reaction condition employing trimethyl orthoformate (TMOF). The role of acetal in promoting the reaction under ambient conditions has been established with control experiments. A range of C3-naphthyl indole derivatives have been synthesized in moderate to very good yields.
- Subjects :
- Cyclization
Catalysis
Acetals
Indoles
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 20
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 36416470
- Full Text :
- https://doi.org/10.1039/d2ob01873j