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Reduction of intrafraction pancreas motion using an abdominal corset compatible with proton therapy and MRI.
- Source :
-
Clinical and translational radiation oncology [Clin Transl Radiat Oncol] 2022 Nov 09; Vol. 38, pp. 111-116. Date of Electronic Publication: 2022 Nov 09 (Print Publication: 2023). - Publication Year :
- 2022
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Abstract
- Background and Purpose: Motion mitigation is of crucial importance in particle therapy (PT) of patients with abdominal tumors to ensure high-precision irradiation. Magnetic resonance imaging (MRI) is an excellent modality for target volume delineation and motion estimation of mobile soft-tissue tumors. Thus, the aims of this study were to develop an MRI- and PT-compatible abdominal compression device, to investigate its effect on pancreas motion reduction, and to evaluate patient tolerability and acceptance.<br />Materials and Methods: In a prospective clinical study, 16 patients with abdominal tumors received an individualized polyethylene-based abdominal corset. Pancreas motion was analyzed using time- and phase resolved MRI scans (orthogonal 2D-cine and 4D MRI) with and without compression by the corset. The pancreas was manually segmented in each MRI data set and the population-averaged center-of-mass motion in inferior-superior (IS), anterior-posterior (AP) and left-right (LR) directions was determined. A questionnaire was developed to investigate the level of patient acceptance of the corset, which the patients completed after acquisition of the planning computed tomography (CT) and MRI scans.<br />Results: The corset was found to reduce pancreas motion predominantly in IS direction by on average 47 % - 51 % as found in the 2D-cine and 4D MRI data, respectively, while motion in the AP and LR direction was not significantly reduced. Most patients reported no discomfort when wearing the corset.<br />Conclusion: An MRI- and PT-compatible individualized abdominal corset was presented, which substantially reduced breathing-induced pancreas motion and can be safely applied with no additional discomfort for the patients. The corset has been successfully integrated into our in-house clinical workflow for PT of tumors of the upper abdomen.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2022 The Author(s).)
Details
- Language :
- English
- ISSN :
- 2405-6308
- Volume :
- 38
- Database :
- MEDLINE
- Journal :
- Clinical and translational radiation oncology
- Publication Type :
- Academic Journal
- Accession number :
- 36407488
- Full Text :
- https://doi.org/10.1016/j.ctro.2022.11.006