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Optical tweezers for drug discovery.
- Source :
-
Drug discovery today [Drug Discov Today] 2023 Jan; Vol. 28 (1), pp. 103443. Date of Electronic Publication: 2022 Nov 14. - Publication Year :
- 2023
-
Abstract
- The time taken and the cost of producing novel therapeutic drugs presents a significant burden - a typical target-based drug discovery process involves computational screening of drug libraries, compound assays and expensive clinical trials. This review summarises the value of dynamic conformational information obtained by optical tweezers and how this information can target 'undruggable' proteins. Optical tweezers provide insights into the link between biological mechanisms and structural conformations, which can be used in drug discovery. Developing workflows including software and sample preparation will improve throughput, enabling adoption of optical tweezers in biopharma. As a complementary tool, optical tweezers increase the number of drug candidates, improve the understanding of a target's complex structural dynamics and elucidate interactions between compounds and their targets.<br /> (Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Drug Discovery
Molecular Conformation
Optical Tweezers
Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5832
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Drug discovery today
- Publication Type :
- Academic Journal
- Accession number :
- 36396117
- Full Text :
- https://doi.org/10.1016/j.drudis.2022.103443