Back to Search Start Over

Development of a hematite nanotube and tyramine-based drug carrier against drug-resistant bacteria Klebsiella pneumoniae .

Authors :
Ali MR
Bacchu MS
Ridoy DD
Mozumder PL
Hasan MN
Das S
Palash MFH
Akter S
Sakib N
Khaleque A
Chakrobortty D
Khan MZH
Source :
RSC advances [RSC Adv] 2022 Nov 03; Vol. 12 (48), pp. 31497-31505. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).
Publication Year :
2022

Abstract

In this study, hematite nanotube (HNT) and tyramine-based advanced nano-drug carriers were developed for inhibiting the growth of Klebsiella pneumoniae ( K. pneumoniae ). The HNT was synthesized by following the Teflon line autoclaved assisted hydrothermal process and tyramine was incorporated on the surface of the HNT to fabricate the formulated nano-drug. The nano-drug was prepared by conjugating meropenem (MP) on the surface of Tyramine-HNT and characterized using different techniques, such as scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR), etc. Furthermore, the drug-loading efficiency and loading capacity were measured using a UV-vis spectrometer. The pH, amount of Tyr, and HNT required for drug loading were optimized. A controlled and gradual manner of pH-sensitive release profiles was found after investigating the release profile of MP from the carrier drug. The antibacterial activity of MP@Tyramine-HNT and MP was compared through the agar disc diffusion method which indicates that antibacterial properties of antibiotics are enhanced after conjugating. Surprisingly, the MP@Tyramine-HNT exhibits a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of K. pneumoniae lower than MP itself. These results indicate the nanocarrier can reduce the amount of MP dosed to eradicate K. pneumoniae .<br />Competing Interests: The authors declared no conflicts of interest.<br /> (This journal is © The Royal Society of Chemistry.)

Details

Language :
English
ISSN :
2046-2069
Volume :
12
Issue :
48
Database :
MEDLINE
Journal :
RSC advances
Publication Type :
Academic Journal
Accession number :
36382147
Full Text :
https://doi.org/10.1039/d2ra05216d