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Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.

Authors :
Xie K
Fuchs H
Scifo E
Liu D
Aziz A
Aguilar-Pimentel JA
Amarie OV
Becker L
da Silva-Buttkus P
Calzada-Wack J
Cho YL
Deng Y
Edwards AC
Garrett L
Georgopoulou C
Gerlini R
Hölter SM
Klein-Rodewald T
Kramer M
Leuchtenberger S
Lountzi D
Mayer-Kuckuk P
Nover LL
Oestereicher MA
Overkott C
Pearson BL
Rathkolb B
Rozman J
Russ J
Schaaf K
Spielmann N
Sanz-Moreno A
Stoeger C
Treise I
Bano D
Busch DH
Graw J
Klingenspor M
Klopstock T
Mock BA
Salomoni P
Schmidt-Weber C
Weiergräber M
Wolf E
Wurst W
Gailus-Durner V
Breteler MMB
Hrabě de Angelis M
Ehninger D
Source :
Nature communications [Nat Commun] 2022 Nov 11; Vol. 13 (1), pp. 6830. Date of Electronic Publication: 2022 Nov 11.
Publication Year :
2022

Abstract

Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to determine when age-dependent change is first detectable relative to the young adult baseline. We examine key lifespan regulators (putative anti-aging interventions; PAAIs) for a possible countering of aging. Importantly, unlike most previous studies, we include in our study design young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. Many PAAI effects influence phenotypes long before the onset of detectable age-dependent change, but, importantly, do not alter the rate of phenotypic change. Hence, these PAAIs have limited effects on aging.<br /> (© 2022. The Author(s).)

Details

Language :
English
ISSN :
2041-1723
Volume :
13
Issue :
1
Database :
MEDLINE
Journal :
Nature communications
Publication Type :
Academic Journal
Accession number :
36369285
Full Text :
https://doi.org/10.1038/s41467-022-34515-y