Consensus guide on prophylactic gonadectomy in different sex development.

Authors :: Guerrero-Fernández J
González-Peramato P
Rodríguez Estévez A
Alcázar Villar MJ
Audí Parera L
Azcona San Julián MC
Carcavilla Urquí A
Castaño González LA
Martos Tello JM
Mora Palma C
Moreno Macián MF
Yeste Fernández D
Nistal M
Source :: Endocrinologia, diabetes y nutricion [Endocrinol Diabetes Nutr (Engl Ed)] 2022 Oct; Vol. 69 (8), pp. 629-645. Date of Electronic Publication: 2022 Nov 08.
Publication Year :: 2022
Abstract: The risk of suffering from gonadal germ cell tumors (GCT) is increased in some patients with different sexual development (DSD), mainly in those with Y chromosome material. This risk, however, varies considerably depending on a multitude of factors that make the decision for prophylactic gonadectomy extremely difficult. In order to make informed recommendations on the convenience of this procedure in cases where there is potential for malignancy, this consensus guide evaluates the latest clinical evidence, which is generally low, and updates the existing knowledge in this field.<br /> (Copyright © 2022 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.)