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Cardiorespiratory fitness decreases the odds for subclinical carotid plaques in apolipoprotein e4 homozygotes.
- Source :
-
Scientific reports [Sci Rep] 2022 Nov 10; Vol. 12 (1), pp. 19196. Date of Electronic Publication: 2022 Nov 10. - Publication Year :
- 2022
-
Abstract
- Some studies suggest that being an apolipoprotein e4 (APOE e4) carrier increases the risk of atherosclerosis, and others suggest that cardiorespiratory fitness (CRF) could play a key role in atherosclerotic prevention. Our aim was to analyze the association of APOE e4 with carotid atherosclerosis and the association of CRF with atherosclerosis in APOE e4 carriers. A cross-sectional analysis based on a subsample of 90 participants in the Aragon Workers' Health Study was carried out. Ultrasonography was used to assess the presence of plaques in carotid territory; the submaximal Chester Step Test was used to assess CRF; and behavioral, demographic, anthropometric, and clinical data were obtained by trained personnel during annual medical examinations. APOE e4e4 participants were categorized into Low-CRF (VO <subscript>2max</subscript> < 35 mL/kg/min) and High-CRF (VO <subscript>2max</subscript> ≥ 35 mL/kg/min) groups. After adjusting for several confounders, compared with APOE e3e3, those participants genotyped as APOE e3e4 and APOE e4e4 showed an OR = 1.60 (95% CI 0.45, 5.71) and OR = 4.29 (95% CI 1.16, 15.91), respectively, for carotid atherosclerosis. Compared to Low-CRF APOE e4e4 carriers, the odds of carotid plaque detection were 0.09 (95% CI 0.008, 0.98) times lower among High-CRF APOE e4e4 carriers. The APOE e4e4 genotype was associated with increased carotid atherosclerosis. However, CRF is a modifiable factor that may be targeted by APOE e4e4 to decrease the elevation of atherosclerotic risk due to this genetic condition.<br /> (© 2022. The Author(s).)
- Subjects :
- Humans
Apolipoprotein E4 genetics
Homozygote
Cross-Sectional Studies
Polymorphism, Genetic
Genotype
Apolipoproteins E genetics
Cardiorespiratory Fitness
Carotid Artery Diseases diagnostic imaging
Carotid Artery Diseases epidemiology
Carotid Artery Diseases genetics
Plaque, Atherosclerotic diagnostic imaging
Atherosclerosis
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 36357490
- Full Text :
- https://doi.org/10.1038/s41598-022-23075-2