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Photodynamic therapy with acai (Euterpe oleracea) and blue light in oral cells: A spectroscopic and cytotoxicity analysis.
- Source :
-
Journal of biophotonics [J Biophotonics] 2023 Mar; Vol. 16 (3), pp. e202200259. Date of Electronic Publication: 2022 Dec 07. - Publication Year :
- 2023
-
Abstract
- Objective: To evaluate the potential of photodynamic therapy (PDT) with blue light-emitting diode (LED) 460 nm at 25, 50 and 100 J/cm <superscript>2</superscript> using three concentrations of acai extracts (100, 40, and 10 mg/ml), in the proliferation and viability of head and neck tumor lines (SCC9).<br />Methods: Three groups of cells were analyzed for 3 days in an in vitro assay with MTT (3- (4,5-dimethylthiazol-2-yl) -2,5, -diphenyltetrazolium bromide) and crystal violet: cells in the absence of acai extract and PDT (control group); cells in the presence of acai extract and no light; and cells in the presence of acai extract and LED blue light (PDT groups).<br />Results: When using acai as a PS combined with blue LED (460 nm, 0.7466 cm <superscript>2</superscript> , 1000 mW/cm <superscript>2</superscript> ) and irradiation at 25, 50, and 100 J/cm <superscript>2</superscript> , after 72 h, cell viability (p < 0.0001 vs. control, p = 0.0027 vs. 100 mg/ml açai group, p = 0.0039 vs. 40 mg/ml açai group, p = 0.0135 vs. 10 mg/ml açai group; One-Way ANOVA/Tukey) and proliferation (p < 0.05, One-Way ANOVA/Tukey) decreased.<br />Conclusion: The acai in question is a potential photosensitizer (PS), with blue light absorbance and efficacy against head and neck tumor lines (SCC9).<br /> (© 2022 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1864-0648
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of biophotonics
- Publication Type :
- Academic Journal
- Accession number :
- 36349809
- Full Text :
- https://doi.org/10.1002/jbio.202200259