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Isolation, Structure Characterization, Total Synthesis and Biological Evaluation of Cinnamic Acid Derivatives from Tinospora sagittata.

Authors :
Xu DF
Su PW
Wang C
Miao L
Zhang JS
Zhang H
Source :
Chemistry & biodiversity [Chem Biodivers] 2022 Dec; Vol. 19 (12), pp. e202200942. Date of Electronic Publication: 2022 Dec 05.
Publication Year :
2022

Abstract

Thirteen cinnamic acid derivatives (1-13), including six formerly unreported hybrids incorporating different short-chain fatty acid esters (1-6), have been obtained and structurally elucidated from an ethnological herb Tinospora sagittata. The structures of them have been established by spectroscopic data analyses and NMR comparison with known analogs, while those of 1, 2, 4 and 6 have been further supported by total synthesis, and it is the first report of this type of metabolites from the title species. All the isolates have been assessed in an array of bioassays encompassing cytotoxic, antibacterial, anti-inflammatory, antioxidant, as well as α-glucosidase and HDAC1 inhibitory models. Compound 7 showed significant inhibitory activity against α-glucosidase, and half of the isolates also displayed moderate antiradical effect.<br /> (© 2022 Wiley-VHCA AG, Zurich, Switzerland.)

Details

Language :
English
ISSN :
1612-1880
Volume :
19
Issue :
12
Database :
MEDLINE
Journal :
Chemistry & biodiversity
Publication Type :
Academic Journal
Accession number :
36346849
Full Text :
https://doi.org/10.1002/cbdv.202200942