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[Primary hypothyroidism and postmenopause as the causes of delayed diagnosis of panhypopituitarism in a patient with nonfunctional pituitary adenoma].
- Source :
-
Problemy endokrinologii [Probl Endokrinol (Mosk)] 2022 Jul 05; Vol. 68 (5), pp. 32-38. Date of Electronic Publication: 2022 Jul 05. - Publication Year :
- 2022
-
Abstract
- Hypopituitarism is a state of complete or partial deficiency of pituitary hormones, including adrenal insufficiency, hypothyroidism, hypogonadism, growth hormone deficiency, and, rarely, diabetes insipidus.The article describes a clinical case of hypopituitarism due to a pituitary tumor in a postmenopausal woman. Difficulties in diagnosing hypopituitarism were due to a history of primary hypothyroidism. The first identified component of panhypopituitarism in the patient, (central hypothyroidism) had previously been seen as laboratory indications of medication-induced hyperthyroidism.The non-specific nature of the clinical symptoms, as well as a relatively rare combination of endocrine diseases, led to a long examination period and delayed diagnosis of the pituitary tumor.Whether the development of hypopituitarism in a patient with a nonfunctional pituitary tumor is an indication for transsphenoidal pituitary surgery remains a controversial issue. The decision for surgery is made taking into account the characteristics of the course of the disease in a particular patient. In this clinical case, a conservative tactic was chosen with hormone replacement therapy for glucocorticoid and thyroid deficiency.
- Subjects :
- Female
Humans
Postmenopause
Delayed Diagnosis adverse effects
Pituitary Neoplasms complications
Pituitary Neoplasms diagnosis
Adenoma complications
Adenoma diagnosis
Hypopituitarism diagnosis
Hypopituitarism etiology
Hypopituitarism drug therapy
Hypothyroidism complications
Hypothyroidism diagnosis
Subjects
Details
- Language :
- Russian
- ISSN :
- 2308-1430
- Volume :
- 68
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Problemy endokrinologii
- Publication Type :
- Academic Journal
- Accession number :
- 36337016
- Full Text :
- https://doi.org/10.14341/probl13128