Back to Search
Start Over
Gynecomastia and Malignancy: A Case of Male Invasive Ductal Breast Carcinoma Treated with Neoadjuvant Chemotherapy.
- Source :
-
The American journal of case reports [Am J Case Rep] 2022 Nov 06; Vol. 23, pp. e937370. Date of Electronic Publication: 2022 Nov 06. - Publication Year :
- 2022
-
Abstract
- BACKGROUND Male breast cancer represents a rare malignancy with identifiable risk factors, including genetics, radiation exposure, liver dysfunction, and concomitant diagnosis of Klinefelter syndrome. Gynecomastia can commonly present in these patients, and despite increased estrogen levels in adipose breast tissue, gynecomastia has not been proven to be a significant risk factor for carcinoma development. Male patients with new-onset breast masses are recommended to undergo diagnostic mammograms and breast ultrasound for further evaluation. Those diagnosed with breast cancer most commonly have invasive ductal carcinoma of the breast, and over half of these patients are found to have estrogen and progesterone receptor (ER/PR) positivity. CASE REPORT In this case report, we present a Black man with gynecomastia and an areolar lesion for a 6-month duration following a traumatic event. He was initially referred to the surgical team for further evaluation, and subsequent imaging and biopsy data revealed ER/PR-positive invasive ductal carcinoma. Multidisciplinary discussions were held, and the patient was arranged to begin neoadjuvant treatment with doxorubicin hydrochloride and cyclophosphamide, followed by treatment with paclitaxel (AC-T) chemotherapy, followed by bilateral mastectomy and adjuvant hormonal therapy. CONCLUSIONS The treatment of male breast cancer has remained relatively like that of female breast cancer, which may be due to the limited data in the treatment of male breast cancer. Thus far, studies involving neoadjuvant chemotherapy of female patients have demonstrated promising responses to expand surgical options for patients and possibly decrease the rates of recurrence. Additional studies are warranted to discern optimal therapy for the male patient population.
- Subjects :
- Humans
Male
Female
Neoadjuvant Therapy
Receptors, Progesterone therapeutic use
Receptor, ErbB-2
Receptors, Estrogen therapeutic use
Mastectomy
Estrogens therapeutic use
Chemotherapy, Adjuvant
Breast Neoplasms pathology
Breast Neoplasms, Male surgery
Gynecomastia etiology
Gynecomastia drug therapy
Gynecomastia surgery
Carcinoma, Ductal drug therapy
Carcinoma, Ductal surgery
Carcinoma, Ductal, Breast therapy
Carcinoma, Ductal, Breast drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1941-5923
- Volume :
- 23
- Database :
- MEDLINE
- Journal :
- The American journal of case reports
- Publication Type :
- Academic Journal
- Accession number :
- 36335424
- Full Text :
- https://doi.org/10.12659/AJCR.937370