MOG-IgG positive optic neuritis after SARS-CoV-2 infection.

Authors :: Gilardi M
Cortese A
Ferraro E
Rispoli M
Sadun R
Altavista MC
Sadun F
Source :: European journal of ophthalmology [Eur J Ophthalmol] 2023 Sep; Vol. 33 (5), pp. NP87-NP90. Date of Electronic Publication: 2022 Nov 01.
Publication Year :: 2023
Abstract: Background: Many neurologic complications have been described after severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) including atypical cases of optic neuritis (ON), positive to myelin oligodendrocyte glycoprotein (MOG) IgG.<br />Objective: To report a case of MOG-IgG-associated ON and discuss why SARS-CoV-2 infection could be a potential trigger.<br />Methods: Retrospective single case report.<br />Results: We report a case of ON with positive MOG-IgG developed 15 days after presentation of SARS-CoV-2 infection.<br />Conclusion: This report suggests that SARS-CoV-2 infection may have triggered autoantibodies production against MOG leading to ON.