Back to Search Start Over

IL-10 regulates Th17 response to inhibit hepatobiliary injury caused by Clonorchis sinensis infection in C57BL/6J mice.

IL-10 regulates Th17 response to inhibit hepatobiliary injury caused by Clonorchis sinensis infection in C57BL/6J mice.

Authors :
Zhang B
Wang J
Liu M
Zhao Q
Yu G
Zhang B
Hua H
Xu J
Li J
Yu Q
Koda S
Xu YH
Jiang Z
Yan C
Zheng KY
Source :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Oct 13; Vol. 12, pp. 994838. Date of Electronic Publication: 2022 Oct 13 (Print Publication: 2022).
Publication Year :
2022

Abstract

Clonorchiasis caused by Clonorchis sinensis is a mainly foodborne parasitic disease. It can lead to hepatobiliary duct inflammation, fibrosis, obstructive jaundice, liver cirrhosis, and even cholangiocarcinoma. Interleukin (IL)-10 is an immune-regulatory cytokine which plays an immunosuppressive role during infection. Our previous study found that IL-10 was increased in mice with C. sinensis infection. However, the role and mechanism of IL-10 playing in hepatobiliary injury induced by C. sinensis infection remain unknown. Herein, Il10 <superscript>+/+</superscript> mice and Il10 <superscript>+/-</superscript> C57BL/6J mice were infected with C. sinensis . It was found that IL-10 deficiency aggravated biliary hyperplasia and exacerbated periductal fibrosis induced by C. sinensis infection. Moreover, IL-10 deficiency increased CD4 <superscript>+</superscript> T cells and CD8 <superscript>+</superscript> T cells but not macrophages in the liver of mice with infection. There were no apparent differences in Th1 and Treg cells between Il10 <superscript>+/+</superscript> and Il10 <superscript>+/-</superscript> mice infected with C. sinensis . However, the proportion of Th17 cells in CD4 <superscript>+</superscript> T cells in Il10 <superscript>+/-</superscript> infected mice was significantly higher than that in Il10 <superscript>+/+</superscript> infected mice. IL-10 deficiency also enhanced the increase of Th17 cells induced by ESPs stimulation in vitro . Taken together, our results suggest that IL-10 plays a protective role in hepatobiliary injury in C57BL/6J mice induced by C. sinensis infection via inhibiting Th17 cells, which could deepen our understanding of the immunopathology of clonorchiasis.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Zhang, Wang, Liu, Zhao, Yu, Zhang, Hua, Xu, Li, Yu, Koda, Xu, Jiang, Yan and Zheng.)

Details

Language :
English
ISSN :
2235-2988
Volume :
12
Database :
MEDLINE
Journal :
Frontiers in cellular and infection microbiology
Publication Type :
Academic Journal
Accession number :
36310865
Full Text :
https://doi.org/10.3389/fcimb.2022.994838