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[Prevalence and risk factors of obesity in children with Diamond-Blackfan anemia].

Authors :
Yi MH
Wan Y
Cheng SQ
Gong XW
Yin ZX
Li J
Gao YY
Wu C
Zong SY
Chang LX
Chen YM
Zheng RX
Zhu XF
Source :
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2022 Oct 15; Vol. 24 (10), pp. 1143-1148.
Publication Year :
2022

Abstract

Objectives: To investigate the distribution of body mass index (BMI) and risk factors for obesity in children with Diamond-Blackfan Anemia (DBA).<br />Methods: The children with DBA who attended National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, from January 2003 to December 2020 were enrolled as subjects. The related clinical data and treatment regimens were recorded. The height and weight data measured within 1 week before or after follow-up time points were collected to calculate BMI. The risk factors for obesity were determined by multivariate regression analysis in children with DBA.<br />Results: A total of 129 children with DBA were enrolled, among whom there were 80 boys (62.0%) and 49 girls (38.0%), with a median age of 49 months (range 3-189 months). The prevalence rate of obesity was 14.7% (19/129). The multivariate logistic regression analysis showed that the absence of ribosomal protein gene mutation was closely associated with obesity in children with DBA (adjusted OR =3.63, 95% CI : 1.16-11.38, adjusted P =0.027). In children with glucocorticoid-dependent DBA, obesity was not associated with age of initiation of glucocorticoid therapy, duration of glucocorticoid therapy, and maintenance dose of glucocorticoids ( P >0.05).<br />Conclusions: There is a high prevalence rate of obesity in children with DBA, and the absence of ribosomal protein gene mutation is closely associated with obesity in children with DBA.

Details

Language :
Chinese
ISSN :
1008-8830
Volume :
24
Issue :
10
Database :
MEDLINE
Journal :
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Publication Type :
Academic Journal
Accession number :
36305116
Full Text :
https://doi.org/10.7499/j.issn.1008-8830.2206070