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Serum Adiponectin, a Novel Biomarker Correlates with Skin Thickness in Systemic Sclerosis.
- Source :
-
Journal of personalized medicine [J Pers Med] 2022 Oct 19; Vol. 12 (10). Date of Electronic Publication: 2022 Oct 19. - Publication Year :
- 2022
-
Abstract
- The aim was to evaluate the longitudinal association between basal serum adiponectin and repeated measurements of skin thickness during 12 months of follow-up in systemic sclerosis (SSc) patients. We enrolled SSc patients with disease duration > 2 years in a prospective observational study. Skin thickness was measured at baseline and after 12 months of follow-up with modified Rodnan skin score (mRSS). Baseline serum adiponectin was determined using a commercial ELISA kit. We enrolled 66 female SSc patients (median age 54 years, IQR 42−62 years). The median disease duration was 12 (IQR 8−16) years and median baseline serum adiponectin was 9.8 (IQR 5.6−15.6) mcg/mL. The median mRSS was 10 (IQR 6−18) at baseline and 12 (IQR 7−18) at follow-up. A significant correlation was observed between baseline serum adiponectin and disease duration (r = 0.264, p < 0.05), age (r = 0.515, p < 0.0001), baseline mRSS (r = −0.303, p < 0.05), and mRSS at follow-up (r = −0.322, p < 0.001). In multiple regression analysis, only mRSS at follow-up showed an inverse correlation with baseline serum adiponectin (β = −0.132, p < 0.01). The reduction in serum adiponectin levels is correlated with skin thickness.
Details
- Language :
- English
- ISSN :
- 2075-4426
- Volume :
- 12
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of personalized medicine
- Publication Type :
- Academic Journal
- Accession number :
- 36294874
- Full Text :
- https://doi.org/10.3390/jpm12101737