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Cytological Diagnosis of Malignant Mesothelioma: A Case Series.

Authors :
Dahiya S
Singh M
Jain S
Khuraijam B
Suroya N
Mandal S
Source :
Journal of cytology [J Cytol] 2022 Jul-Sep; Vol. 39 (3), pp. 105-109. Date of Electronic Publication: 2022 Jul 30.
Publication Year :
2022

Abstract

Background: Mesotheliomas are neoplasms of the serosal lining of the body cavities. Diagnosis requires a multimodal approach of clinical findings, cytology, and histopathology with immunohistochemistry (IHC). The published sensitivity of cytology for diagnosing mesothelioma ranges from 30% to 75%.<br />Aim and Objectives: This study aimed to calculate the incidence of malignant mesothelioma (MM) at our institute and to study the cytological features of MM.<br />Materials and Methods: A retrospective study of pleural, peritoneal, and pericardial fluids submitted at our institute was done. The duration of the study was 8 years (2011-2019). Apart from examining Giemsa smears, a panel of immunocytochemical (ICC) and cell block immunohistochemical (IHC) markers was applied to achieve the diagnosis. These included calretinin, mesothelin, CK5/6, Hector Battifora mesothelial cell antibody (HBME), WT1, MOC31, CK7 and CK20. Histopathological correlation was done wherever possible.<br />Result: In the present study, we compiled four cases of MM over 8 years diagnosed on serous effusion cytology and confirmed by immunocytochemistry (ICC)/cell block immunohistochemistry (IHC)/biopsy. This indicates a rare incidence of MM. The Cytological features of MM were studied.<br />Conclusion: The diagnosis of MM is difficult, especially cytologically. It was found to be a rare entity in the malignant cases diagnosed on effusion cytology.<br />Competing Interests: There are no conflicts of interest.<br /> (Copyright: © 2022 Journal of Cytology.)

Details

Language :
English
ISSN :
0970-9371
Volume :
39
Issue :
3
Database :
MEDLINE
Journal :
Journal of cytology
Publication Type :
Academic Journal
Accession number :
36277806
Full Text :
https://doi.org/10.4103/joc.joc_145_21