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Stereotactic radiosurgery as the initial management option for small-volume hypothalamic hamartomas with intractable epilepsy: a 35-year institutional experience and systematic review.
- Source :
-
Journal of neurosurgery. Pediatrics [J Neurosurg Pediatr] 2022 Oct 21; Vol. 31 (1), pp. 52-60. Date of Electronic Publication: 2022 Oct 21 (Print Publication: 2023). - Publication Year :
- 2022
-
Abstract
- Objective: Young patients with hypothalamic hamartomas (HHs) often present with intractable epilepsy. Currently there are no established management guidelines for HH. The authors retrospectively reviewed their single-institution experience to delineate the role of stereotactic radiosurgery (SRS).<br />Methods: Seven patients with HHs (4 females; median age 13.7 years, range 2.5-25 years) with no prior resection underwent SRS between 1987 and 2022. The clinical history, epilepsy profile, radiographic findings, and neurological outcomes were characterized. HH topographical types were classified according to the Régis classification. Outcome measures included Engel seizure classification, HH response, and the need for additional surgical interventions.<br />Results: All patients had Engel class IV epilepsy. A Leksell Gamma Knife was used to deliver a median margin dose of 18 Gy (range 16-20 Gy) to a median hamartoma volume of 0.37 cm3 (range 0.20-0.89 cm3). Seizure reduction was confirmed in 6 patients, and 2 patients had regression of their hamartoma. Two patients underwent resection and/or laser interstitial thermal therapy after SRS. At follow-up, 1 patient was seizure free, 4 patients achieved Engel class II, 1 patient had Engel class III, and 1 patient had Engel class IV seizure outcomes.<br />Conclusions: SRS as the initial management option for HH was associated with a low risk of adverse effects. In this institutional series reviewing small-volume HHs treated with SRS, no adverse radiation effect was detected, and the majority of patients experienced seizure reduction. SRS should be considered as the first-line treatment for seizure control in patients with small-volume HHs.
- Subjects :
- Adolescent
Adult
Child
Child, Preschool
Female
Humans
Young Adult
Follow-Up Studies
Retrospective Studies
Seizures surgery
Treatment Outcome
Male
Drug Resistant Epilepsy surgery
Drug Resistant Epilepsy complications
Epilepsy etiology
Epilepsy radiotherapy
Epilepsy surgery
Hamartoma complications
Hamartoma radiotherapy
Hamartoma surgery
Hypothalamic Diseases complications
Hypothalamic Diseases radiotherapy
Hypothalamic Diseases surgery
Radiosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 1933-0715
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neurosurgery. Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 36272114
- Full Text :
- https://doi.org/10.3171/2022.9.PEDS22200