Contemporary Epidemiology of Primary Biliary Cholangitis.

Primary biliary cholangitis (PBC) is a cholestatic liver disease with potential evolution to liver cirrhosis when left untreated. Despite being rare, PBC has a substantial impact on the quality of life and survival of affected patients. Women are the most diagnosed worldwide; however, male subjects seem to have more aggressive disease and worse prognosis. Changing epidemiologic trends are emerging in PBC, with increasing global prevalence and slight smoothing of sex differences. In this review we present available data on incidence rates and prevalence of PBC worldwide, highlighting geographic differences and factors impacting clinical outcomes.
Competing Interests: Conflict of interest A. Lleo has received consulting fees from Intercept Pharma, AlfaSigma, and Takeda, lecture fees from AbbVie, Gilead, Takeda, AlfaSigma and MSD and travel expenses from Intercept Pharma, AlfaSigma, and AbbVie. F. Colapietro and A. Bertazzoni reported no conflict of interest.
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