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Photoswitchable Microgels for Dynamic Macrophage Modulation.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2022 Dec; Vol. 34 (49), pp. e2205498. Date of Electronic Publication: 2022 Nov 02. - Publication Year :
- 2022
-
Abstract
- Dynamic manipulation of supramolecular self-assembled structures is achieved irreversibly or under non-physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed of azobenzene derivatives stacked via π-cation and π-π interactions are developed that are electrostatically stabilized with Arg-Gly-Asp (RGD)-bearing anionic polymers. Lateral swelling of RGD-bearing microgels occurs via cis-azobenzene formation mediated by near-infrared-light-upconverted ultraviolet light, which disrupts intermolecular interactions on the visible-light-absorbing upconversion-nanoparticle-coated materials. Real-time imaging and molecular dynamics simulations demonstrate the deswelling of RGD-bearing microgels via visible-light-mediated trans-azobenzene formation. Near-infrared light can induce in situ swelling of RGD-bearing microgels to increase RGD availability and trigger release of loaded interleukin-4, which facilitates the adhesion structure assembly linked with pro-regenerative polarization of host macrophages. In contrast, visible light can induce deswelling of RGD-bearing microgels to decrease RGD availability that suppresses macrophage adhesion that yields pro-inflammatory polarization. These microgels exhibit high stability and non-toxicity. Versatile use of ligands and protein delivery can offer cytocompatible and photoswitchable manipulability of diverse host cells.<br /> (© 2022 Wiley-VCH GmbH.)
- Subjects :
- Macrophages
Microgels
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 34
- Issue :
- 49
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 36268986
- Full Text :
- https://doi.org/10.1002/adma.202205498