Vitamin D status can affect COVID-19 outcomes also in pediatric population.

Authors :: Miraglia Del Giudice M
Indolfi C
Dinardo G
Decimo F
Decimo A
Klain A
Source :: PharmaNutrition [PharmaNutrition] 2022 Dec; Vol. 22, pp. 100319. Date of Electronic Publication: 2022 Oct 14.
Publication Year :: 2022
Abstract: Background: vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D's role in the pathophysiology of COVID-19 disease.<br />Results: the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID-19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population.<br />Conclusions: further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2022 Published by Elsevier B.V.)