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Multicomponent reactions as a privileged tool for multitarget-directed ligand strategies in Alzheimer's disease therapy.
- Source :
-
Future medicinal chemistry [Future Med Chem] 2022 Nov; Vol. 14 (21), pp. 1583-1606. Date of Electronic Publication: 2022 Oct 20. - Publication Year :
- 2022
-
Abstract
- Among neurodegenerative pathologies affecting the older population, Alzheimer's disease is the most common type of dementia and leads to neurocognitive and behavioral disorders. It is a complex and progressive age-related multifactorial disease characterized by a series of highly interconnected pathophysiological processes. Within the last decade, the multitarget-directed ligand strategy has emerged as a viable approach to developing complex molecules that exhibit several pharmacophores which can target the different enzymes and receptors involved in the pathogenesis of the disease. Herein, we focus on using multicomponent reactions such as Hantzsch, Biginelli and Ugi to develop these biologically active multitopic ligands.
- Subjects :
- Humans
Ligands
Cholinesterase Inhibitors
Alzheimer Disease
Subjects
Details
- Language :
- English
- ISSN :
- 1756-8927
- Volume :
- 14
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Future medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 36263996
- Full Text :
- https://doi.org/10.4155/fmc-2022-0170