Curcumin-based ionic Pt(II) complexes: antioxidant and antimicrobial activity.

Authors :: Caligiuri R
Di Maio G
Godbert N
Scarpelli F
Candreva A
Rimoldi I
Facchetti G
Lupo MG
Sicilia E
Mazzone G
Ponte F
Romeo I
La Deda M
Crispini A
De Rose R
Aiello I
Source :: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2022 Nov 08; Vol. 51 (43), pp. 16545-16556. Date of Electronic Publication: 2022 Nov 08.
Publication Year :: 2022
Abstract: A series of novel cationic curcumin-based Pt(II) complexes with neutral (N^N) ligands and triflate anions as counterions, [(N^N)Pt(curc)]CF <subscript>3</subscript> SO <subscript>3</subscript> , 1-4, were synthesised and fully characterised. The antioxidant radical scavenging activity of complexes 1-4 was measured spectrophotometrically using DPPH as the internal probe. Computational strategies have been exploited to ascertain the mechanism of antioxidant action of curcumin (H(curc)) and its Pt(II) complexes. Finally, compounds 1-4 were tested in vitro for their growth inhibitory activity against two bacteria ( Staphylococcus aureus and Escherichia coli ) by the disk diffusion technique at different Pt(II) complex solution concentrations. The effect of the complexation of H(curc) was investigated.