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Antenatal corticosteroids in Singapore: a clinical and scientific assessment.
- Source :
-
Singapore medical journal [Singapore Med J] 2024 Sep 01; Vol. 65 (9), pp. 479-487. Date of Electronic Publication: 2022 Oct 06. - Publication Year :
- 2024
-
Abstract
- Abstract: Preterm birth (PTB; delivery prior to 37 weeks' gestation) is the leading cause of early childhood death in Singapore today. Approximately 9% of Singaporean babies are born preterm; the PTB rate is likely to increase given the increased use of assisted reproduction technologies, changes in the incidence of gestational diabetes/high body mass index and the ageing maternal population. Antenatal administration of dexamethasone phosphate is a key component of the obstetric management of Singaporean women who are at risk of imminent preterm labour. Dexamethasone improves preterm outcomes by crossing the placenta to functionally mature the fetal lung. The dexamethasone regimen used in Singapore today affords a very high maternofetal drug exposure over a brief period of time. Drawing on clinical and experimental data, we reviewed the pharmacokinetic profile and pharmacodynamic effects of dexamethasone treatment regimen in Singapore, with a view to creating a development pipeline for optimising this critically important antenatal therapy.<br /> (Copyright © 2024 Copyright: © 2024 Singapore Medical Journal.)
- Subjects :
- Humans
Pregnancy
Singapore
Female
Infant, Newborn
Prenatal Care methods
Adrenal Cortex Hormones therapeutic use
Adrenal Cortex Hormones administration & dosage
Obstetric Labor, Premature drug therapy
Obstetric Labor, Premature prevention & control
Dexamethasone therapeutic use
Premature Birth prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 2737-5935
- Volume :
- 65
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Singapore medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 36254928
- Full Text :
- https://doi.org/10.4103/SINGAPOREMEDJ.SMJ-2022-014