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New polyphenolic glycosides from the stems of Caesalpinia cucullata and their inhibitory effect on methicillin-resistant Staphylococcus aureus with different ways.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2022 Dec; Vol. 129, pp. 106193. Date of Electronic Publication: 2022 Oct 10. - Publication Year :
- 2022
-
Abstract
- Anti-virulence strategy represents an emerging alternative strategy in the war against increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) due to its milder selection pressure on bacterial resistance. Sortase A (SrtA), as an important virulence factor, is a membrane-localized cysteine transpeptidase which anchors cell surface proteins to the cell wall. Natural products in medicinal plants are the source of targeting bacterial virulence factors. Here, we found polyphenolic glycosides (1-15), including thirteen new derivatives isolated from the stems of Caesalpinia cucullata, exhibited weak to moderate SrtA inhibitory activity without affecting the growth of MRSA, and compound 7 (53.7 % inhibition at 100 μM) was superior to the positive control curcumin. Meanwhile, compounds 2, 4 and 8 could effectively reduce the dose of ceftiofur in combination in vitro with fractional inhibitory concentration index (FICI) ranging from 0.188 to 0.375, which meant polyphenolic glycosides have got antibacterial activity with different ways. Here, we reported all new compounds structures determined by spectroscopy methods and their antibacterial activities, together, the relationship between structures with the inhibitory efficiency. The results indicated that polyphenolic glycosides could be used as promising therapeutic agents to prevent resistance development for S. aureus infections.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Subjects :
- Microbial Sensitivity Tests
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Caesalpinia chemistry
Glycosides chemistry
Glycosides isolation & purification
Glycosides pharmacology
Methicillin-Resistant Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 129
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 36242982
- Full Text :
- https://doi.org/10.1016/j.bioorg.2022.106193