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Heparin modulates human intestinal smooth muscle cell proliferation, protein synthesis, and lattice contraction.
- Source :
-
Gastroenterology [Gastroenterology] 1987 Oct; Vol. 93 (4), pp. 801-9. - Publication Year :
- 1987
-
Abstract
- The effect of heparin on human intestinal smooth muscle cell proliferation, collagen and noncollagen protein synthesis, and collagen lattice contraction was studied in vitro. Proliferation of serum-stimulated cells was inhibited in a concentration-related fashion by continuous exposure to heparin. The inhibition of proliferation was reversible when heparin was removed from the culture medium. Collagen synthesis was inhibited by 24-h exposure to heparin, but only during that phase of culture (8-12 days) when collagen synthesis was maximal. Noncollagen protein synthesis was down-regulated by 24-h exposure to heparin at all phases of culture tested (5-21 days). Heparin also abolished the contraction of collagen lattices populated by human intestinal smooth muscle cells. These studies demonstrate that heparin plays a significant role in the modulation of human intestinal smooth muscle cell behavior in vitro and suggest that a similar role is played by heparinlike components of the extracellular matrix in vivo.
Details
- Language :
- English
- ISSN :
- 0016-5085
- Volume :
- 93
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 3623023
- Full Text :
- https://doi.org/10.1016/0016-5085(87)90443-4