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Critical functions of N 6 -adenosine methylation of mRNAs in T cells.
- Source :
-
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2023 Jan; Vol. 1870 (1), pp. 119380. Date of Electronic Publication: 2022 Oct 11. - Publication Year :
- 2023
-
Abstract
- The existence of N <superscript>6</superscript> -adenosine methylation (m <superscript>6</superscript> A) of mRNA has been known for a long time, but only recently its regulatory potential was uncovered. Current research deciphers the molecular determinants leading to the deposition of this modification and consequences for modified mRNAs. It also evaluates the importance of such modifications for specific cell types and programs. In this review, we summarize the current knowledge on m <superscript>6</superscript> A modification of mRNAs in conventional and regulatory T cells and T-cell-driven immune responses and pathology. We discuss the impact of m <superscript>6</superscript> A modification on T cell activation including cytokine and antigen receptor signaling or sensing of double-stranded RNAs (dsRNA).<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-2596
- Volume :
- 1870
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta. Molecular cell research
- Publication Type :
- Academic Journal
- Accession number :
- 36228837
- Full Text :
- https://doi.org/10.1016/j.bbamcr.2022.119380