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99m Technetium-pyrophosphate bone scan: A potential biomarker for the burden of transthyretin amyloidosis in skeletal muscle: A preliminary study.
- Source :
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Muscle & nerve [Muscle Nerve] 2023 Feb; Vol. 67 (2), pp. 111-116. Date of Electronic Publication: 2022 Oct 31. - Publication Year :
- 2023
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Abstract
- Introduction/aims: Transthyretin amyloidosis (ATTR) proteins can infiltrate skeletal muscle and infrequently cause a myopathy. <superscript>99m</superscript> Technetium-pyrophosphate ( <superscript>99m</superscript> Tc-PYP) is a validated biomarker for cardiac involvement in variant and wild-type ATTR (ATTRv and ATTRwt, respectively). The aim of this study was to test the hypothesis that <superscript>99m</superscript> Tc-PYP is a biomarker for muscle burden of ATTR.<br />Methods: Radioisotope uptake in the deltoid muscles of patients with ATTR was compared to uptake in control subjects without amyloidosis in a retrospective study. <superscript>99m</superscript> Tc-PYP scans were evaluated in 11 patients with ATTR (7 ATTRv, 4 ATTRwt) and 14 control subjects. Mean count (MC) values were measured in circular regions of interest (ROIs) 2.5-3.8 cm <superscript>2</superscript> in area. Tracer uptake was quantified in the heart, contralateral chest (CC), and deltoid muscles.<br />Results: Tracer uptake was significantly higher over the deltoids and heart but not the CC, in patients with ATTR than in control subjects. MC values were 120.1 ± 43.7 (mean ± SD) in ATTR patients and 78.9 ± 20.4 in control subjects over the heart (p = 0.005), 73.3± 21.0 and 63.5 ± 14.4 over CC (p = 0.09), and 37.0 ± 11.7 and 26.0 ± 7.1 averaged over both deltoid muscles (p = 0.014).<br />Discussion: <superscript>99m</superscript> Tc-PYP is a potential biomarker for ATTR amyloid burden in skeletal muscle.<br /> (© 2022 The Authors. Muscle & Nerve published by Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1097-4598
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Muscle & nerve
- Publication Type :
- Academic Journal
- Accession number :
- 36222831
- Full Text :
- https://doi.org/10.1002/mus.27740