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Core concepts in pharmacoepidemiology: Key biases arising in pharmacoepidemiologic studies.
- Source :
-
Pharmacoepidemiology and drug safety [Pharmacoepidemiol Drug Saf] 2023 Jan; Vol. 32 (1), pp. 9-18. Date of Electronic Publication: 2022 Oct 20. - Publication Year :
- 2023
-
Abstract
- Pharmacoepidemiology has an increasingly important role in informing and improving clinical practice, drug regulation, and health policy. Therefore, unrecognized biases in pharmacoepidemiologic studies can have major implications when study findings are translated to the real world. We propose a simple taxonomy for researchers to use as a starting point when thinking through some of the most pervasive biases in pharmacoepidemiology. We organize this discussion according to biases best assessed with respect to the study population (including confounding by indication, channeling bias, healthy user bias, and protopathic bias), the study design (including prevalent user bias and immortal time bias), and the data source (including misclassification bias and missing data/loss to follow up). This tutorial defines, provides a curated list of recommended references, and illustrates through relevant case examples these key biases to consider when planning, conducting, or evaluating pharmacoepidemiologic studies.<br /> (© 2022 John Wiley & Sons Ltd.)
- Subjects :
- Humans
Bias
Health Policy
Pharmacoepidemiology methods
Research Design
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1557
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmacoepidemiology and drug safety
- Publication Type :
- Academic Journal
- Accession number :
- 36216785
- Full Text :
- https://doi.org/10.1002/pds.5547