Covid-19, nervous system pathology, and Parkinson's disease: Bench to bedside.

Authors :: Emmi A
Boura I
Raeder V
Mathew D
Sulzer D
Goldman JE
Leta V
Source :: International review of neurobiology [Int Rev Neurobiol] 2022; Vol. 165, pp. 17-34. Date of Electronic Publication: 2022 Aug 09.
Publication Year :: 2022
Abstract: Coronavirus disease 2019 (Covid-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is primarily regarded as a respiratory disease; however, multisystemic involvement accompanied by a variety of clinical manifestations, including neurological symptoms, are commonly observed. There is, however, little evidence supporting SARS-CoV-2 infection of central nervous system cells, and neurological symptoms for the most part appear to be due to damage mediated by hypoxic/ischemic and/or inflammatory insults. In this chapter, we report evidence on candidate neuropathological mechanisms underlying neurological manifestations in Covid-19, suggesting that while there is mostly evidence against SARS-CoV-2 entry into brain parenchymal cells as a mechanism that may trigger Parkinson's disease and parkinsonism, that there are multiple means by which the virus may cause neurological symptoms.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)