Locking down SOS Mutagenesis Repression in a Dynamic Pathogen.

Authors :: Gregg-Jolly LA
Source :: Journal of bacteriology [J Bacteriol] 2022 Nov 15; Vol. 204 (11), pp. e0022022. Date of Electronic Publication: 2022 Oct 04.
Publication Year :: 2022
Abstract: The article "The DdrR coregulator of the Acinetobacter baumannii mutagenic DNA damage response potentiates UmuDAb repression of error-prone polymerases" in this issue of the J Bacteriol, (D. Cook, M. D. Flannigan, B. V. Candra, K. D. Compton, and J. M. Hare., J Bacteriol 204:e00165-22, 2022, https://doi.org/10.1128/jb.00165-22) reveals a more detailed understanding of the regulatory mechanism of the SOS response in Acinetobacter baumannii. This information provides novel targets for development of antimicrobial therapies against this ESKAPE pathogen and new insight into the complex regulation of the SOS stress-response.