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Rab3 and synaptotagmin proteins in the regulation of vesicle fusion and neurotransmitter release.
- Source :
-
Life sciences [Life Sci] 2022 Nov 15; Vol. 309, pp. 120995. Date of Electronic Publication: 2022 Sep 24. - Publication Year :
- 2022
-
Abstract
- Ca <superscript>2+</superscript> -triggered neurotransmitter release involves complex regulatory mechanisms, including a series of protein-protein interactions. Three proteins, synaptobrevin (VAMP), synaptosomal-associated protein of 25kDa (SNAP-25) and syntaxin, constitute the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) core complex that plays key roles in controlling vesicle fusion and exocytosis. Many other proteins participate in the regulation of the processes via direct and/or indirect interaction with the SNARE complex. Although much effort has been made, the regulatory mechanism for exocytosis is still not completely clear. Accumulated evidence indicates that the small GTPase Rab3 and synaptotagmin proteins play important regulatory roles during vesicle fusion and neurotransmitter release. This review outlines our present understanding of the two regulatory proteins, with the focus on the interaction of Rab3 with synaptotagmin in the regulatory process.<br />Competing Interests: Declaration of competing interest The authors declare no competing interests.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Subjects :
- Synaptotagmins
Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins metabolism
Synaptosomal-Associated Protein 25 metabolism
Exocytosis physiology
R-SNARE Proteins
Qa-SNARE Proteins metabolism
Neurotransmitter Agents
Calcium metabolism
Nerve Tissue Proteins metabolism
Monomeric GTP-Binding Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 309
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 36167148
- Full Text :
- https://doi.org/10.1016/j.lfs.2022.120995