The Microbiome in Gastrointestinal Cancers.

Authors :: White MG
Wargo JA
Source :: Gastroenterology clinics of North America [Gastroenterol Clin North Am] 2022 Sep; Vol. 51 (3), pp. 667-680. Date of Electronic Publication: 2022 Aug 29.
Publication Year :: 2022
Abstract: The human microbiome has been recognized as increasingly important to health and disease. This is especially prescient in the development of various cancers, their progression, and the microbiome's modulation of various anticancer therapeutics. Mechanisms behind these interactions have been increasingly well described through modulation of the host immune system as well as induction of genetic changes and local inactivation of cancer therapeutics. Here, we review these associations for a variety of gastrointestinal malignancies as well as contemporary strategies proposed to leverage these associations to improve cancer treatment outcomes.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)