Cancer in Inflammatory Bowel Disease.

Authors :: Faye AS
Holmer AK
Axelrad JE
Source :: Gastroenterology clinics of North America [Gastroenterol Clin North Am] 2022 Sep; Vol. 51 (3), pp. 649-666. Date of Electronic Publication: 2022 Aug 30.
Publication Year :: 2022
Abstract: Inflammatory bowel diseases (IBD), including Crohn disease and ulcerative colitis, are chronic inflammatory conditions of the gastrointestinal tract. Individuals with IBD are at increased risk for several malignancies originating in the intestine, such as colorectal cancer, small bowel adenocarcinoma, intestinal lymphoma, and anal cancer. There are also several extraintestinal malignancies associated with IBD and IBD therapies, including cholangiocarcinoma, skin cancer, hematologic malignancies, genitourinary cancer, cervical cancer, and prostate cancer. The authors summarize the risk of cancer in patients with IBD, diagnosis and management of colorectal neoplasia in IBD, and management of patients with IBD and active or recent cancer.<br />Competing Interests: Disclosure J.E. Axelrad reports receiving research grants from BioFire Diagnostics; consultancy fees or honorarium from BioFire Diagnostics, Janssen, Pfizer, Abbvie, and BMS; and holds US Patent 2012/0052124A1 and no other conflicts of interest. A.K. Holmer reports consultancy fees or honorarium from Pfizer.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)