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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2022 Sep 12; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 12. - Publication Year :
- 2022
-
Abstract
- We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates' selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 27
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 36144662
- Full Text :
- https://doi.org/10.3390/molecules27185923