Brusatol: A potential anti-tumor quassinoid from Brucea javanica .

Authors :: Yu XQ
Shang XY
Huang XX
Yao GD
Song SJ
Source :: Chinese herbal medicines [Chin Herb Med] 2020 Aug 19; Vol. 12 (4), pp. 359-366. Date of Electronic Publication: 2020 Aug 19 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Brusatol, a triterpene lactone compound mainly from Brucea javanica , sensitizes a broad spectrum of cancer cells. It is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. In this review, we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in vivo . This review also covers pharmacokinetics studies, modification of dosages forms of brusatol. Increasing evidences have validated the value of brusatol as a chemotherapeutic agent in cancers, which may contribute to drug development and clinical application.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2020 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.)