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Juvenile Granulosa Cell Tumor Mimicking HAIR-AN in a 4-year-old: A Case Report
- Source :
-
Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2024 May 31; Vol. 16 (2), pp. 200-204. Date of Electronic Publication: 2022 Sep 16. - Publication Year :
- 2024
-
Abstract
- Predominantly androgen secreting juvenile granulosa cell tumors (JGCT) are uncommon and few reports have been published. We present a case of a JGCT that presented with signs of prepubertal hyperandrogenism and insulin resistance to highlight the possible interaction between hyperandrogenemia and hyperinsulinism. A 4-year-old girl presented with acanthosis nigricans and hyperinsulinism, mimicking the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome at an age much younger than is typical for this diagnosis. Laboratory studies revealed elevated insulin, inhibin A and B, and total testosterone. All laboratory results normalized after unilateral salpingo-oophorectomy. The final diagnosis was Stage 1A JGCT. This case highlights the importance of including ovarian tumors in the differential diagnosis when considering causes of virilization and insulin resistance. This case also suggests a potential relationship between excess testosterone secretion and hyperinsulinemia and strengthens evidence that hyperandrogenemia may promote hyperinsulinism in ovarian disease.<br /> (©Copyright 2024 by Turkish Society for Pediatric Endocrinology and Diabetes / The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.)
- Subjects :
- Humans
Female
Child, Preschool
Diagnosis, Differential
Acanthosis Nigricans diagnosis
Hyperinsulinism diagnosis
Insulin Resistance
Granulosa Cell Tumor diagnosis
Granulosa Cell Tumor pathology
Ovarian Neoplasms diagnosis
Ovarian Neoplasms pathology
Hyperandrogenism diagnosis
Hyperandrogenism etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1308-5735
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of clinical research in pediatric endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 36112066
- Full Text :
- https://doi.org/10.4274/jcrpe.galenos.2022.2022-4-17